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girl with down syndrome sleeping

Characteristics of central breathing abnormalities in children with trisomy 21

girl with down syndrome sleeping

Trisomy 21 (TS21), also known as Down syndrome, is the most common genetic syndrome in the United States. Many children with TS21 have a higher prevalence of sleep-related breathing disorders including central sleep apnea. While the mechanisms of central sleep apnea in TS21 are not completely understood, children with Down syndrome have multiple factors that make them more susceptible to developing central breathing abnormalities, including nervous system impairment, hypothyroidism and hypotonia.

In a recent multi-institutional study published in the journal Pediatric Pulmonology, Gustavo Nino, M.D., MSHS, D’ABSM, director of sleep medicine at Children’s National Hospital, and colleagues investigated the clinical features of central breathing abnormalities in TS21 across different pediatric age groups. The researchers also conducted analyses to look at the effects of biological sex and concomitant obstructive sleep apnea in children with central breathing abnormalities.

The authors conclude that “central breathing abnormalities are common in TS21 among young children (≤2 years of age) and in females older than 2 years of age,” and that “central apnea is often associated with concomitant obstructive sleep apnea and/or hypoxemia in children with TS21.”

Read the full study in Pediatric Pulmonology.

NASPGHAN meeting logo

Children’s National Gastroenterology team presents virtually at NASPGHAN conference

NASPGHAN meeting logo

The North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) conference provides experts with an advanced understanding of the normal pediatric development and physiology of diseases of the gastrointestinal tract and liver.

The Children’s National Hospital gastroenterology team was due to present in-person at the conference but were unable to as a result of the COVID-19 pandemic. Instead they presented educational sessions virtually to gastroenterology experts across the country. The presentations spanned a variety of topics and are listed below:

  • Trisomy 21: Not all duodenal abnormalities are Celiac Disease
  • Celiac Kids Research Consortium (CeliacKIDS)
  • Postoperative complications in pediatric IBD patients on biologic therapy undergoing intra-abdominal surgery
  • 6 week infliximab trough levels as predictor of therapeutic maintenance infliximab trough levels and patient outcomes
  • Inflammatory bowel disease characteristics in pediatric patients of South Asian origin in the United States
  • Investigating treatment response rates in pediatric inflammatory bowel disease patients after switching biologics
  • Severely elevated fecal calprotectin in a pediatric patient with persistent giardiasis
  • Persistent hypoglycemia after treatment of gestational alloimmune liver disease (GALD)

The 2021 annual conference will be held on November 4-6 in Nashville, Tennessee.