Effect of antibiotics on microorganisms and lung function in children with CF

Cystic fibrosis (CF) is a disease that affects many people, especially children. Pulmonary exacerbations (PEx) are common in people with CF and can cause a decline in lung function. These PEx are often treated with antibiotics, but little is known about how antibiotics affect the airway microbiome (the collection of microorganisms in the lungs) of people with CF over time.

Experts from Children’s National Hospital took part in a recent study which looked at how the airway microbiome and lung function of children with CF changed over the course of a year following an initial PEx. The study found that the diversity of the airway microbiome increased over the year despite a decrease in lung function associated with repeated PEx events requiring antibiotic therapy. This suggests that repeated treatment with antibiotics may not have a negative impact on the overall diversity of microorganisms in the lungs.

It is important for pediatricians to understand how antibiotics affect the airway microbiome in children with CF because it can help them make more informed decisions about treatment options. The findings of this study suggest that the use of antibiotics to treat PEx in children with CF may not be as detrimental to the airway microbiome as previously thought. This information can help pediatricians provide better care for children with CF and ultimately improve their overall health outcomes.

You can read the full study, Impact of Antibiotics on the Lung Microbiome and Lung Function in Children With Cystic Fibrosis 1 Year After Hospitalization for an Initial Pulmonary Exacerbation, in Open Forum Infectious Diseases.

Authors on the study from Children’s National Hospital include Zaina Inam, M.D., Aszia Burrell, Hollis Chaney, M.D., Iman Sami-Zakhari, M.D., Anastassios Koumbourlis, M.D., M.P.H., Robert J. Freishtat, M.D., M.P.H., and Andrea Hahn, M.D., M.S.