Therapy approach shows promise for PANS/PANDAS

PANS and PANDAS are disorders characterized by an abrupt onset of neuropsychiatric symptoms in children that can be challenging to diagnose and treat.
Children diagnosed with pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) experienced substantial symptom reduction following a cognitive-behavioral approach integrating the family system with the support of a multidisciplinary care team, according to a recent case study published in Clinical Case Studies.
The hold up in the field
PANS and PANDAS are disorders characterized by an abrupt onset of neuropsychiatric symptoms in children that can be challenging to diagnose and treat.
“More research is needed to explore PANS/PANDAS as many studies have included small samples or lacked a randomized controlled design,” says Lilia Mucka Andrew, PhD, clinical director, Psychology and Behavioral Health at Children’s National Hospital and corresponding author of the study. “Though therapeutic interventions like cognitive behavioral therapy with exposure response prevention (CBT/ERP) have good evidence for pediatric patients with obsessive-compulsive disorder (OCD), evidence is mixed on effectiveness in PANS/PANDAS patients.”
Moving the field forward
The researchers highlighted specific intervention techniques that worked well to improve behaviors and factors that warrant further exploration. This includes the benefit of early multidisciplinary evaluation for diagnosis and treatment of PANS/PANDAS and the integration of booster sessions to allow for ongoing maintenance and relapse prevention while providing openings for additional patients to be seen. This is critical given the shortage of evidence based behavioral health providers for youth.
The patient benefit
This study highlights effective strategies that support both patients and their families, offering a potential model of care to reduce suffering and improve long-term quality of life.
“We were excited to see that the application of key evidence-based therapy techniques including CBT/ERP and behavioral parent training (BPT) resulted in positive outcomes for patients and that the opportunity to transition to booster sessions was well received,” says Dr. Andrew.
Additional authors from Children’s National include: Julia Dorfman, MD, PhD, psychiatrist, and Elizabeth Wells, MD, senior vice president, Neuroscience and Behavioral Medicine Center.
You can read the full study, Assessment and Treatment of PANS/PANDAS: A Multidisciplinary Approach and Therapeutic Considerations, in Clinical Case Studies.