Entries by Diedtra Henderson

Destructive otologic foreign body – dangers of the expanding bead

What’s Known Superabsorbent polymers (SAP), such as polyacrylamide, are water-soluble plastics with high absorption capacities that frequently are used in agriculture, within potting soil, and as disposable diaper filler. Of late, the material has been used to manufacture children’s playthings. Toys made of SAP include firm colorful beads, known as jelly beads, initially sized at 0.1 cm to 0.2 cm in diameter that swell to […]

Analysis of a progressive diffuse intrinsic pontine glioma: a case report

What’s Known Despite multiple clinical trials testing an assortment of new treatments, the survival rate for diffuse intrinsic pontine glioma (DIPG) remains abysmal, with most children succumbing to the pediatric brainstem tumor within 12 months of diagnosis. Focal radiation therapy, the primary treatment approach, has not improved overall survival. While the majority of DIPG tumors grow within the brainstem, metastases can […]

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

What’s Known Needle biopsies help to guide diagnosis and targeted therapies for diffuse intrinsic pontine gliomas (DIPGs), which make up 10 percent to 15 percent of all pediatric brain tumors but carry a median survival of 9 to 12 months. This dismal survival rate compares with a 70 percent chance of children surviving other central […]

The role of NG2 proteoglycan in glioma

What’s Known Neuron glia antigen-2 (NG2) is a protein expressed by many central nervous system cells during development and differentiation. NG2-expressing oligodendrocyte progenitor cells have been identified as the cells of origin in gliomas, tumors that arise from the brain’s gluey supportive tissue. What’s more, NG2 expression also has been associated with childhood diffuse intrinsic […]

Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape

What’s Known Fewer than 150 U.S. children per year are diagnosed with diffuse intrinsic pontine glioma (DIPG), one of the most lethal pediatric central nervous system cancers. Despite an increasing number of experimental therapies tested via clinical trials, more than 95 percent of these children die within two years of diagnosis. Molecular studies have yielded […]