An explosion of innovative work conducted by researchers that include a multidisciplinary team at Children’s National Health System promises to change the narrative for pediatric diffuse intrinsic pontine glioma.
About Diedtra Henderson
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Entries by Diedtra Henderson
A team conducted the first-ever family echocardiographic screening study over three months to help identify optimal strategies to pinpoint the families in Northern Uganda at highest latent rheumatic heart disease risk.
A team led by Children’s National Health System researchers identified 21 biomarkers that respond to corticosteroids taken daily by children with Duchenne muscular dystrophy and inflammatory bowel disease.
What’s Known Superabsorbent polymers (SAP), such as polyacrylamide, are water-soluble plastics with high absorption capacities that frequently are used in agriculture, within potting soil, and as disposable diaper filler. Of late, the material has been used to manufacture children’s playthings. Toys made of SAP include firm colorful beads, known as jelly beads, initially sized at 0.1 cm to 0.2 cm in diameter that swell to […]
What’s Known Despite multiple clinical trials testing an assortment of new treatments, the survival rate for diffuse intrinsic pontine glioma (DIPG) remains abysmal, with most children succumbing to the pediatric brainstem tumor within 12 months of diagnosis. Focal radiation therapy, the primary treatment approach, has not improved overall survival. While the majority of DIPG tumors grow within the brainstem, metastases can […]
What’s Known Needle biopsies help to guide diagnosis and targeted therapies for diffuse intrinsic pontine gliomas (DIPGs), which make up 10 percent to 15 percent of all pediatric brain tumors but carry a median survival of 9 to 12 months. This dismal survival rate compares with a 70 percent chance of children surviving other central […]
What’s Known Neuron glia antigen-2 (NG2) is a protein expressed by many central nervous system cells during development and differentiation. NG2-expressing oligodendrocyte progenitor cells have been identified as the cells of origin in gliomas, tumors that arise from the brain’s gluey supportive tissue. What’s more, NG2 expression also has been associated with childhood diffuse intrinsic […]
What’s Known Fewer than 150 U.S. children per year are diagnosed with diffuse intrinsic pontine glioma (DIPG), one of the most lethal pediatric central nervous system cancers. Despite an increasing number of experimental therapies tested via clinical trials, more than 95 percent of these children die within two years of diagnosis. Molecular studies have yielded […]